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Oct 29, 2014
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Liu, Qinghua; Zhang, Kun; Zhuang, Yan; Li, Zhong; Yu, Bin; Pei, Guoxian
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This article is from PLoS ONE , volume 8 . Abstract Background: Studies of syndesmosis injuries have concentrated on cadaver models. However, they are unable to obtain exact data regarding the stress and displacement distribution of various tissues, and it is difficult to compare models. We investigated the biomechanical effects of inferior tibiofibular syndesmosis injuries (ITSIs) and screw fixation on the ankle using the finite element (FE) method. Methodology/Principal Findings: A...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848989
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Oct 26, 2014
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Dorries, Kirsten; Lalk, Michael
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This article is from PLoS ONE , volume 8 . Abstract During infection processes, Staphylococcus aureus is able to survive within the host and to invade tissues and cells. For studying the interaction between the pathogenic bacterium and the host cell, the bacterial growth behaviour and its metabolic adaptation to the host cell environment provides first basic information. In the present study, we therefore cultivated S. aureus COL and HG001 in the eukaryotic cell culture medium RPMI 1640 and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849228
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Oct 24, 2014
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Li, Ningfeng Fiona; Gemenetzidis, Emilios; Marshall, Francis J.; Davies, Derek; Yu, Yongwei; Frese, Kristopher; Froeling, Fieke E. M.; Woolf, Adam K.; Feakins, Roger M.; Naito, Yoshiki; Iacobuzio-Donahue, Christine; Tuveson, David A.; Hart, Ian R.; Kocher, Hemant M.
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This article is from PLoS ONE , volume 8 . Abstract Human pancreatic ductal adenocarcinoma (PDAC) is characterized by early systemic dissemination. Although RhoC has been implicated in cancer cell migration, the relevant underlying molecular mechanisms remain unknown. RhoC has been implicated in the enhancement of cancer cell migration and invasion, with actions which are distinct from RhoA (84% homology), and are possibly attributed to the divergent C-terminus domain. Here, we confirm that...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849283
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Oct 25, 2014
10/14
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Hoppner, Hannes; McIntyre, Joseph; van der Smagt, Patrick
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This article is from PLoS ONE , volume 8 . Abstract It is widely known that the pinch-grip forces of the human hand are linearly related to the weight of the grasped object. Less is known about the relationship between grip force and grip stiffness. We set out to determine variations to these dependencies in different tasks with and without visual feedback. In two different settings, subjects were asked to (a) grasp and hold a stiffness-measuring manipulandum with a predefined grip force,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852021
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Oct 29, 2014
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de Paula Silva, Pedro H.; Paul, Nicholas A.; de Nys, Rocky; Mata, Leonardo
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This article is from PLoS ONE , volume 8 . Abstract Intensive algal cultivation usually requires a high flux of dissolved inorganic carbon (Ci) to support productivity, particularly for high density algal cultures. Carbon dioxide (CO2) enrichment can be used to overcome Ci limitation and enhance productivity of algae in intensive culture, however, it is unclear whether algal species with the ability to utilise bicarbonate (HCO3−) as a carbon source for photosynthesis will benefit from CO2...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852247
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Oct 24, 2014
10/14
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Umar, Meenakshi; Upadhyay, Rohit; Kumar, Shaleen; Ghoshal, Uday Chand; Mittal, Balraj
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This article is from PLoS ONE , volume 8 . Abstract Background: Tumour necrosis factor-alpha (TNF-α) and nuclear factor of kappa light chain gene enhancer in activated B cells (NF-κB) play critical role in carcinogenesis processes like tumour initiation, proliferation, migration and invasion. Single nucleotide polymorphisms in TNF-α, NF-κB and its inhibitor IκB genes were shown to be associated with susceptibility and prognosis of several cancers; however, their role in esophageal squamous...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852749
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Oct 28, 2014
10/14
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Soveri, Anna; Waris, Otto; Laine, Matti
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This article is from PLoS ONE , volume 8 . Abstract The very few cognitive training studies targeting an important executive function, set shifting, have reported performance improvements that also generalized to untrained tasks. The present randomized controlled trial extends set shifting training research by comparing previously used cued training with uncued training. A computerized adaptation of the Wisconsin Card Sorting Test was utilized as the training task in a pretest-posttest...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852728
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Oct 27, 2014
10/14
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Pasin, Laura; Greco, Teresa; Feltracco, Paolo; Vittorio, Annalisa; Neto, Caetano Nigro; Cabrini, Luca; Landoni, Giovanni; Finco, Gabriele; Zangrillo, Alberto
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This article is from PLoS ONE , volume 8 . Abstract Introduction: The effect of dexmedetomidine on length of intensive care unit (ICU) stay and time to extubation is still unclear. Materials and Methods: Pertinent studies were independently searched in BioMedCentral, PubMed, Embase, and the Cochrane Central Register of clinical trials (updated February first 2013). Randomized studies (dexmedetomidine versus any comparator) were included if including patients mechanically ventilated in an...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877008
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Oct 24, 2014
10/14
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Zhu, Qian-Hao; Fan, Longjiang; Liu, Yang; Xu, Hao; Llewellyn, Danny; Wilson, Iain
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This article is from PLoS ONE , volume 8 . Abstract In this study, we characterized the miR482 family in cotton using existing small RNA datasets and the recently released draft genome sequence of Gossypium raimondii, a diploid cotton species whose progenitor is the putative contributor of the Dt (representing the D genome of tetraploid) genome of the cultivated tetraploid cotton species G. hirsutum and G. barbadense. Of the three ghr-miR482 members reported in G. hirsutum, ghr-miR482a has no...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877274
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Oct 28, 2014
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Yang, Meng; Zhang, Wan; Dong, Huaxia; Zhang, Yuanyuan; Lv, Kai; Wang, Dujun; Lian, Xingming
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This article is from PLoS ONE , volume 8 . Abstract Manganese (Mn) is an essential trace element for plants. Recently, the genes responsible for uptake of Mn in plants were identified in Arabidopsis and rice. However, the mechanism of Mn distribution in plants has not been clarified. In the present study we identified a natural resistance-associated macrophage protein (NRAMP) family gene in rice, OsNRAMP3, involved in Mn distribution. OsNRAMP3 encodes a plasma membrane-localized protein and was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877151
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Oct 28, 2014
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Baussano, Iacopo; Elfstrom, K. Miriam; Lazzarato, Fulvio; Gillio-Tos, Anna; De Marco, Laura; Carozzi, Francesca; Del Mistro, Annarosa; Dillner, Joakim; Franceschi, Silvia; Ronco, Guglielmo
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This article is from PLoS ONE , volume 8 . Abstract Infection with high-risk (hr) human papillomavirus (HPV) is considered the necessary cause of cervical cancer. Vaccination against HPV16 and 18 types, which are responsible of about 75% of cervical cancer worldwide, is expected to have a major global impact on cervical cancer occurrence. Valid estimates of the parameters that regulate the natural history of hrHPV infections are crucial to draw reliable projections of the impact of vaccination....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882251
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Oct 28, 2014
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Lotem, Joseph; Levanon, Ditsa; Negreanu, Varda; Leshkowitz, Dena; Friedlander, Gilgi; Groner, Yoram
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This article is from PLoS ONE , volume 8 . Abstract The transcription factor Runx3 is highly expressed in CD8+ T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3-/- primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827420
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Oct 28, 2014
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Chakrabarti, Abhijit; Bhattacharya, Dipankar; Deb, Sanghamitra; Chakraborty, Madhumita
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This article is from PLoS ONE , volume 8 . Abstract Apart from few early biophysical studies, the relative thermal instability of HbE has been only shown by clinical investigations. We have compared in vitro thermal stability of HbE with HbA2 and HbA using optical spectroscopy. From absorption measurements in the soret region, synchronous fluorescence spectroscopy and dynamic light scattering experiments, we have found thermal stability of the three hemoglobin variants following the order...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828284
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Oct 28, 2014
10/14
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Zhou, Jie; Dovidio, John; Wang, Erping
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This article is from PLoS ONE , volume 8 . Abstract The moderating role of affective-cognitive consistency in the effects of affectively-based and cognitively-based attitudes on consummatory and instrumental behaviors was explored using two experimental studies in the intergroup context. Study 1 revealed that affectively-based attitudes were better predictors than cognitively-based attitudes regardless of affective-cognitive consistency for consummatory behaviors (e.g., undergraduates’...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828264
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Oct 25, 2014
10/14
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Quraishi, Sadeq A.; Bittner, Edward A.; Christopher, Kenneth B.; Camargo, Carlos A.
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This article is from PLoS ONE , volume 8 . Abstract Objective: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] level and history of community-acquired pneumonia (CAP). Patients and Methods: We identified 16,975 individuals (≥17 years) from the third National Health and Nutrition Examination Survey (NHANES III) with documented 25(OH)D levels. To investigate the association of 25(OH)D with history of CAP in these participants, we developed a multivariable logistic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829945
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Oct 26, 2014
10/14
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D'Uva, Gabriele; Bertoni, Sara; Lauriola, Mattia; De Carolis, Sabrina; Pacilli, Annalisa; D'Anello, Laura; Santini, Donatella; Taffurelli, Mario; Ceccarelli, Claudio; Yarden, Yosef; Montanaro, Lorenzo; Bonafe, Massimiliano; Storci, Gianluca
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This article is from PLoS ONE , volume 8 . Abstract Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms gain importance over the energy-expensive gene transcription machinery. Here we show that the onset of hypoxia-induced cancer stem cell features requires the beta-catenin-dependent post-transcriptional up-regulation of CA9 and SNAI2 gene expression. In response to hypoxia, beta-catenin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829939
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Oct 24, 2014
10/14
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Zou, Ying-Ning; Wu, Qiang-Sheng; Huang, Yong-Ming; Ni, Qiu-Dan; He, Xin-Hua
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This article is from PLoS ONE , volume 8 . Abstract Proline accumulation was often correlated with drought tolerance of plants infected by arbuscular mycorrhizal fungi (AMF), whereas lower proline in some AM plants including citrus was also found under drought stress and the relevant mechanisms have not been fully elaborated. In this study proline accumulation and activity of key enzymes relative to proline biosynthesis (▵1-pyrroline-5-carboxylate synthetase, P5CS;...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832396
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Oct 24, 2014
10/14
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Ervasti, Jenni; Vahtera, Jussi; Pentti, Jaana; Oksanen, Tuula; Ahola, Kirsi; Kivimaki, Mika; Virtanen, Marianna
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This article is from PLoS ONE , volume 8 . Abstract Objective: Depression is a major cause of disability in working populations and the reduction of socioeconomic inequalities in disability is an important public health challenge. We examined work disability due to depression with four indicators of socioeconomic status. Methods: A prospective cohort study of 125 355 Finnish public sector employees was linked to national register data on work disability (>9 days) due to depressive disorders...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835932
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Oct 27, 2014
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Stahl, Mirjam; Schupp, Jonas; Jager, Benedikt; Schmid, Michael; Zissel, Gernot; Muller-Quernheim, Joachim; Prasse, Antje
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This article is from PLoS ONE , volume 8 . Abstract Idiopathic pulmonary fibrosis is characterized by abundant collagen production and accumulation of alternatively activated macrophages (M2) in the lower respiratory tract. Mechanisms as to how alveolar macrophages are activated by collagen breakdown products are unknown. Alveolar macrophages were obtained by bronchoalveolar lavage from 30 patients with idiopathic pulmonary fibrosis (IPF) and 37 healthy donors (HD). Alveolar macrophages were...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835428
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Oct 28, 2014
10/14
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Butala, Neel M.; Chang, Harry; Horwitz, Leora I.; Bartlett, Mary; Ellis, Peter
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This article is from PLoS ONE , volume 8 . Abstract : Student-run clinics increasingly serve as primary care providers for patients of lower socioeconomic status, but studies show that quality of care at student-run clinics has room for improvement. Purpose: To examine change in provision of preventive services in a student-run free clinic after implementation of a student-led QI intervention involving prompting. Method: Review of patient charts pre- and post-intervention, examining adherence...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836795
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Oct 28, 2014
10/14
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Jiang, Wei; Yu, Hai-tao; Zhao, Ke; Zhang, Ye; Du, Hong; Wang, Ping-zhong; Bai, Xue-fan
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This article is from PLoS ONE , volume 8 . Abstract Hantaan virus (HTNV) is a major zoonotic pathogen that causes hemorrhagic fever with renal syndrome (HFRS) in Asia, especially in China. Shaanxi province, which is located in northwest of China, is one of the areas in China most severely afflicted with HFRS epidemics annually. This study aims to establish a quantitative RT-PCR (qRT-PCR) assay to detect HTNV both in cell culture and clinical serum samples. We established a SYBR Green Ⅰ-based...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836762
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Oct 28, 2014
10/14
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Shimizu, Kazuya; Chiba, Sachie; Hori, Yuichi
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This article is from PLoS ONE , volume 8 . Abstract Pancreatic ductal adenocarcinoma is highly resistant to systemic chemotherapy. Although there are many reports using pancreatic cancer cells derived from patients who did not receive chemotherapy, characteristics of pancreatic cancer cells from chemotherapy-resistant patients remain unclear. In this study, we set out to establish a cancer cell line in disseminated cancer cells derived from gemcitabine-resistant pancreatic ductal adenocarcinoma...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836917
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Oct 24, 2014
10/14
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Castaneda, Beatriz; Simon, Yohann; Ferbus, Didier; Robert, Benoit; Chesneau, Julie; Mueller, Christopher; Berdal, Ariane; Lezot, Frederic
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This article is from PLoS ONE , volume 8 . Abstract The MSX2 homeoprotein is implicated in all aspects of craniofacial skeletal development. During postnatal growth, MSX2 is expressed in all cells involved in mineralized tissue formation and plays a role in their differentiation and function. Msx2 null (Msx2−/−) mice display complex craniofacial skeleton abnormalities with bone and tooth defects. A moderate form osteopetrotic phenotype is observed, along with decreased expression of RANKL...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836916
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Oct 29, 2014
10/14
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Togashi, Kazuya; Wakatsuki, Shuji; Furuno, Akiko; Tokunaga, Shinji; Nagai, Yoshitaka; Araki, Toshiyuki
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This article is from PLoS ONE , volume 8 . Abstract In polyglutamine diseases, an abnormally elongated polyglutamine results in protein misfolding and accumulation of intracellular aggregates. Autophagy is a major cellular degradative pathway responsible for eliminating unnecessary proteins, including polyglutamine aggregates. Basal autophagy constitutively occurs at low levels in cells for the performance of homeostatic function, but the regulatory mechanism for basal autophagy remains...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836979
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Oct 26, 2014
10/14
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Liu, Jiewei; Numata, Shusuke; Ikeda, Masashi; Watanabe, Yuichiro; Zheng, Xue-bin; Luo, Xiongjian; Kinoshita, Makoto; Nunokawa, Ayako; Someya, Toshiyuki; Ohmori, Tetsuro; Bei, Jin-xin; Chong, Siow-Ann; Lee, Jimmy; Li, Zhiqiang; Liu, Jianjun; Iwata, Nakao; Shi, Yongyong; Li, Ming; Su, Bing
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This article is from PLoS ONE , volume 8 . Abstract Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838413
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Oct 28, 2014
10/14
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Shi, Ting; Wang, Guanglu; Wang, Zhiwen; Fu, Jing; Chen, Tao; Zhao, Xueming
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This article is from PLoS ONE , volume 8 . Abstract Bacillus subtilis has been a model for gram-positive bacteria and it has long been exploited for industrial and biotechnological applications. However, the availability of facile genetic tools for physiological analysis has generally lagged substantially behind traditional genetic models such as Escherichia coli and Saccharomyces cerevisiae. In this work, we have developed an efficient, precise and scarless method for rapid multiple genetic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839881
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Oct 26, 2014
10/14
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Crous-Bou, Marta; Rennert, Gad; Cuadras, Daniel; Salazar, Ramon; Cordero, David; Saltz Rennert, Hedy; Lejbkowicz, Flavio; Kopelovich, Levy; Monroe Lipkin, Steven; Bernard Gruber, Stephen; Moreno, Victor
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This article is from PLoS ONE , volume 8 . Abstract Background: Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epidemiological risk factors for CRC included alcohol intake, which is mainly metabolized to acetaldehyde by alcohol dehydrogenase and further oxidized to acetate by aldehyde dehydrogenase; consequently, the role of genes in the alcohol metabolism pathways is of particular interest. The aim of this study is to analyze the association between SNPs in ADH1B and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839967
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Oct 25, 2014
10/14
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Tofoli de Araujo, Fabiano; Bolanos-Garcia, Victor M.; Pereira, Cristiane T.; Sanches, Mario; Oshiro, Elisa E.; Ferreira, Rita C. C.; Chigardze, Dimitri Y.; Barbosa, Joao Alexandre Goncalves; de Souza Ferreira, Luis Carlos; Benedetti, Celso E.; Blundell, Tom L.; Balan, Andrea
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This article is from PLoS ONE , volume 8 . Abstract Background: The uptake of sulphur-containing compounds plays a pivotal role in the physiology of bacteria that live in aerobic soils where organosulfur compounds such as sulphonates and sulphate esters represent more than 95% of the available sulphur. Until now, no information has been available on the uptake of sulphonates by bacterial plant pathogens, particularly those of the Xanthomonas genus, which encompasses several pathogenic species....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839906
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Oct 27, 2014
10/14
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Lorenzi, Luisa; Tabellini, Giovanna; Vermi, William; Moratto, Daniele; Porta, Fulvio; Notarangelo, Lucia D.; Patrizi, Ornella; Sozzani, Silvano; de Saint Basile, Genevieve; Latour, Sylvain; Pace, David; Lonardi, Silvia; Facchetti, Fabio; Badolato, Raffaele; Parolini, Silvia
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This article is from PLoS ONE , volume 8 . Abstract Hermansky Pudlak type 2 syndrome (HPS2) is a rare autosomal recessive primary immune deficiency caused by mutations on β3A gene (AP3B1 gene). The defect results in the impairment of the adaptor protein 3 (AP-3) complex, responsible for protein sorting to secretory lysosomes leading to oculo-cutaneous albinism, bleeding disorders and immunodeficiency. We have studied peripheral blood and lymph node biopsies from two siblings affected by HPS2....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841159
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Oct 27, 2014
10/14
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Painting, Christina. J.; Holwell, Gregory I.
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This article is from PLoS ONE , volume 8 . Abstract Sexual selection has driven the evolution of exaggerated traits among diverse animal taxa. The production of exaggerated traits can come at a cost to other traits through trade-offs when resources allocated to trait development are limited. Alternatively some traits can be selected for in parallel to support or compensate for the cost of bearing the exaggerated trait. Male giraffe weevils (Lasiorhynchus barbicornis) display an extremely...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842246
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Oct 27, 2014
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Ellegaard, Kirsten Maren; Klasson, Lisa; Andersson, Siv G. E.
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This article is from PLoS ONE , volume 8 . Abstract The multiple displacement amplification method has revolutionized genomic studies of uncultured bacteria, where the extraction of pure DNA in sufficient quantity for next-generation sequencing is challenging. However, the method is problematic in that it amplifies the target DNA unevenly, induces the formation of chimeric reads and also amplifies contaminating DNA. Here, we have tested the reproducibility of the multiple displacement...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842359
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Oct 24, 2014
10/14
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Luef, Eva Maria; Pika, Simone
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This article is from PLoS ONE , volume 8 . Abstract The present paper describes two distinct behaviors relating to food processing and communication that were observed in a community of five separately housed groups of lowland gorillas (Gorilla gorilla gorilla) in captivity during two study periods one decade apart: (1) a food processing technique to separate wheat from chaff, the so-called puff-blowing technique; and (2) a male display used to attract the attention of visitors, the so-called...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842280
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Oct 28, 2014
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Ruhi, Albert; Boix, Dani; Gascon, Stephanie; Sala, Jordi; Batzer, Darold P.
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This article is from PLoS ONE , volume 8 . Abstract In freshwater ecosystems, species compositions are known to be determined hierarchically by large to small‑scale environmental factors, based on the biological traits of the organisms. However, in ephemeral habitats this heuristic framework remains largely untested. Although temporary wetland faunas are constrained by a local filter (i.e., desiccation), we propose its magnitude may still depend on large-scale climate characteristics. If this...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842952
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Oct 27, 2014
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Ouyang, Ping; Arif, Mohammad; Fletcher, Jacqueline; Melcher, Ulrich; Ochoa Corona, Francisco Manuel
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This article is from PLoS ONE , volume 8 . Abstract A reliable, accurate and rapid multigene-based assay combining real time quantitative PCR (qPCR) and a Razor Ex BioDetection System (Razor Ex) was validated for detection of Xylella fastidiosa subsp. pauca (Xfp, a xylem-limited bacterium that causes citrus variegated chlorosis [CVC]). CVC, which is exotic to the United States, has spread through South and Central America and could significantly impact U.S. citrus if it arrives. A method for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843690
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Oct 28, 2014
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Osaki, Yohei; Yokohama, Akihiko; Saito, Akio; Tahara, Kenichi; Yanagisawa, Kunio; Ogawa, Yoshiyuki; Ishizaki, Takuma; Mitsui, Takeki; Koiso, Hiromi; Takizawa, Makiko; Uchiumi, Hideki; Saitoh, Takayuki; Handa, Hiroshi; Murakami, Hirokazu; Tsukamoto, Norifumi; Nojima, Yoshihisa
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This article is from PLoS ONE , volume 8 . Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy. Plasmacytoid DCs (pDCs), which are defined as lineage marker (Lin)−HLA−DR+CD56−CD123+CD11c− cells, are considered to be the normal counterpart of BPDCNs. However, BPDCN can be distinguished from pDCs by uniform expression of CD56. In this study, to identify a normal counterpart of BPDCN, we searched for a Lin−HLA−DR+CD56+ population and focused...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843704
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Oct 24, 2014
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Mishra, Deo; Vishnupriya, Manne Ramachander; Anil, Madhusoodana Girija; Konda, Kotilingam; Raj, Yog; Sonti, Ramesh V.
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This article is from PLoS ONE , volume 8 . Abstract A number of rice resistance genes, called Xa genes, have been identified that confer resistance against various strains of Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial blight. An understanding of pathotype diversity within the target pathogen population is required for identifying the Xa genes that are to be deployed for development of resistant rice cultivars. Among 1024 isolates of Xoo collected from 20 different states...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843720
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Oct 27, 2014
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Bowling, Daniel L.; Herbst, Christian T.; Fitch, W. Tecumseh
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This article is from PLoS ONE , volume 8 . Abstract Humans have a capacity to perceive and synchronize with rhythms. This is unusual in that only a minority of other species exhibit similar behavior. Study of synchronizing species (particularly anurans and insects) suggests that simultaneous signal production by different individuals may play a critical role in the development of regular temporal signaling. Accordingly, we investigated the link between simultaneous signal production and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843660
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Oct 24, 2014
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Kim, Kyutae; Park, Seong-Jun; Na, Seungjin; Kim, Jun Seok; Choi, Hyungwon; Kim, Yoon Ki; Paek, Eunok; Lee, Cheolju
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This article is from PLoS ONE , volume 8 . Abstract Twenty different aminoacyl-tRNA synthetases (ARSs) link each amino acid to their cognate tRNAs. Individual ARSs are also associated with various non-canonical activities involved in neuronal diseases, cancer and autoimmune diseases. Among them, eight ARSs (D, EP, I, K, L, M, Q and RARS), together with three ARS-interacting multifunctional proteins (AIMPs), are currently known to assemble the multi-synthetase complex (MSC). However, the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846882
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Oct 24, 2014
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Shi, Yuting; Wang, Junling; Li, Jia-Da; Ren, Haigang; Guan, Wenjuan; He, Miao; Yan, Weiqian; Zhou, Ying; Hu, Zhengmao; Zhang, Jianguo; Xiao, Jingjing; Su, Zheng; Dai, Meizhi; Wang, Jun; Jiang, Hong; Guo, Jifeng; Zhou, Yafang; Zhang, Fufeng; Li, Nan; Du, Juan; Xu, Qian; Hu, Yacen; Pan, Qian; Shen, Lu; Wang, Guanghui; Xia, Kun; Zhang, Zhuohua; Tang, Beisha
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This article is from PLoS ONE , volume 8 . Abstract Autosomal recessive cerebellar ataxias are a group of neurodegenerative disorders that are characterized by complex clinical and genetic heterogeneity. Although more than 20 disease-causing genes have been identified, many patients are still currently without a molecular diagnosis. In a two-generation autosomal recessive cerebellar ataxia family, we mapped a linkage to a minimal candidate region on chromosome 16p13.3 flanked by...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846781
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Oct 28, 2014
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Lafontaine, Marc Philippe; Theoret, Hugo; Gosselin, Frederic; Lippe, Sarah
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This article is from PLoS ONE , volume 8 . Abstract Repeated visual processing of an unfamiliar face suppresses neural activity in face-specific areas of the occipito-temporal cortex. This "repetition suppression" (RS) is a primitive mechanism involved in learning of unfamiliar faces, which can be detected through amplitude reduction of the N170 event-related potential (ERP). The dorsolateral prefrontal cortex (DLPFC) exerts top-down influence on early visual processing. However, its...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852506
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Oct 28, 2014
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Zetterstrom, Caroline E.; Hasselgren, Jenny; Salin, Olli; Davis, Rohan A.; Quinn, Ronald J.; Sundin, Charlotta; Elofsson, Mikael
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This article is from PLoS ONE , volume 8 . Abstract Society faces huge challenges, as a large number of bacteria have developed resistance towards many or all of the antibiotics currently available. Novel strategies that can help solve this problem are urgently needed. One such strategy is to target bacterial virulence, the ability to cause disease e.g., by inhibition of type III secretion systems (T3SSs) utilized by many clinically relevant gram-negative pathogens. Many of the antibiotics used...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853165
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Oct 26, 2014
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Kawahara, Takeo; Hotta, Naoe; Ozawa, Yukiko; Kato, Seiichi; Kano, Keiko; Yokoyama, Yukihiro; Nagino, Masato; Takahashi, Takashi; Yanagisawa, Kiyoshi
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This article is from PLoS ONE , volume 8 . Abstract Elucidation of how pancreatic cancer cells give rise to distant metastasis is urgently needed in order to provide not only a better understanding of the underlying molecular mechanisms, but also to identify novel targets for greatly improved molecular diagnosis and therapeutic intervention. We employed combined proteomic technologies including mass spectrometry and isobaric tags for relative and absolute quantification peptide tagging to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855176
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Oct 24, 2014
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Tsukuba, Takayuki; Yanagawa, Michiyo; Kadowaki, Tomoko; Takii, Ryosuke; Okamoto, Yoshiko; Sakai, Eiko; Okamoto, Kuniaki; Yamamoto, Kenji
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eye 46
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This article is from PLoS ONE , volume 8 . Abstract Cathepsin E is an endosomal aspartic proteinase that is predominantly expressed in immune-related cells. Recently, we showed that macrophages derived from cathepsin E-deficient (CatE−/−) mice display accumulation of lysosomal membrane proteins and abnormal membrane trafficking. In this study, we demonstrated that CatE−/− macrophages exhibit abnormalities in autophagy, a bulk degradation system for aggregated proteins and damaged...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855462
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Oct 28, 2014
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Chase Grey, Julia N.; Kent, Vivien T.; Hill, Russell A.
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eye 71
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This article is from PLoS ONE , volume 8 . Abstract Populations of large carnivores can persist in mountainous environments following extensive land use change and the conversion of suitable habitat for agriculture and human habitation in lower lying areas of their range. The significance of these populations is poorly understood, however, and little attention has focussed on why certain mountainous areas can hold high densities of large carnivores and what the conservation implications of such...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857283
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Oct 28, 2014
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Wacker, Katrin; Denker, Sophy; Hildebrand, Antonia; Eberwein, Philipp; Reinhard, Thomas; Schwartzkopff, Johannes
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This article is from PLoS ONE , volume 8 . Abstract Background: Any inflammatory response following corneal transplantation may induce rejection and irreversible graft failure. The purpose of this study is to analyze the anti-inflammatory effect of azithromycin (AZM) following experimental keratoplasty in rats. Methods: Corneal transplants were performed between Fisher-donor and Lewis-recipient rats. Recipients were postoperatively treated three times daily with AZM, miglyol, ofloxacin or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857254
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Oct 26, 2014
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Silva-Gomes, Sandro; Bouton, Cecile; Silva, Tania; Santambrogio, Paolo; Rodrigues, Pedro; Appelberg, Rui; Gomes, Maria Salome
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This article is from PLoS ONE , volume 8 . Abstract Important for both host and pathogen survivals, iron is a key factor in determining the outcome of an infectious process. Iron with-holding, including sequestration inside tissue macrophages, is considered an important strategy to fight infection. However, for intra-macrophagic pathogens, such as Mycobacterium avium, host defence may depend on intracellular iron sequestration mechanisms. Ferritin, the major intracellular iron storage protein,...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857292
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Oct 24, 2014
10/14
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Gao, Yongping; Hou, Qi; Wang, Haoyan
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eye 53
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This article is from PLoS ONE , volume 8 . Abstract Subject: Chronic obstructive pulmonary disease (COPD) is a common disease worldwide. This study aimed to investigate the health status of patients with newly diagnosed COPD. Methods: A total of 45 healthy controls and 218 patients with newly diagnosed COPD were recruited. Pulmonary function test (PFT) values, COPD assessment test (CAT) scores, exacerbation history, and demographics were recorded. Results: Forced expiratory volume in 1 s...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857270
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Oct 28, 2014
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Poddar, Rajesh; Kawai, Risa; Olveczky, Bence P.
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eye 54
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This article is from PLoS ONE , volume 8 . Abstract Addressing the neural mechanisms underlying complex learned behaviors requires training animals in well-controlled tasks, an often time-consuming and labor-intensive process that can severely limit the feasibility of such studies. To overcome this constraint, we developed a fully computer-controlled general purpose system for high-throughput training of rodents. By standardizing and automating the implementation of predefined training...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857823
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Oct 28, 2014
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Bret, Celine; Sueur, Cedric; Ngoubangoye, Barthelemy; Verrier, Delphine; Deneubourg, Jean-Louis; Petit, Odile
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eye 77
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This article is from PLoS ONE , volume 8 . Abstract The difficulty involved in following mandrills in the wild means that very little is known about social structure in this species. Most studies initially considered mandrill groups to be an aggregation of one-male/multifemale units, with males occupying central positions in a structure similar to those observed in the majority of baboon species. However, a recent study hypothesized that mandrills form stable groups with only two or three...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858359
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Oct 24, 2014
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Preissner, Sarah C.; Hoffmann, Michael F.; Preissner, Robert; Dunkel, Mathias; Gewiess, Andreas; Preissner, Saskia
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This article is from PLoS ONE , volume 8 . Abstract The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than 2,000 mutations have been described, and certain single nucleotide polymorphisms (SNPs) have been shown to have a large impact on CYP activity. Therefore, CYPs play an important role in inter-individual drug response and their genetic variability should be factored into personalized medicine. To identify the most relevant polymorphisms in human CYPs, a text...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858335
